Current Source Analysis of Interictal Spikes in Two Patients With Gelastic Epilepsy-Hypothalamic Hamartoma Syndrome

J Korean Neurol Assoc > Volume 27(3); 2009 > Article

Journal of the Korean Neurological Association 2009;27(3): 237-242.

홍소발작-시상하부과오종증후군 환자 두 명의 발작간극파 전류원분석

정승욱, 권오영a,b 정석원a 하은옥a 이수민a 강규식a,b 강희영a,b 박기종a,b 최낙천a,b 임병훈a,b

경상대학교 의학전문대학원 신경과학교실a, 경상대학교 건강과학연구원b

Current Source Analysis of Interictal Spikes in Two Patients With Gelastic Epilepsy-Hypothalamic Hamartoma Syndrome

Seunguk Jung

Department of Neurology, Gyeongsang National University School of Medicinea, Jinju, Korea Gyeongsang Institute of Health Science, Gyeongsang National Universityb, Jinju, Korea

Abstract

Background: Interictal spikes in gelastic epilepsy-hypothalamic hamartoma syndrome are mainly in the fronto-temporal area. Current source analysis of the interictal spikes has not been done enough. We tried the current source analysis in 2 patients with gelastic epilepsy-hypothalamic hamartoma syndrome using both of the discrete and distributed models.
Methods: Twenty 1 sec epochs including the negative peak of the spikes, were selected from one or two electroencephalographic recordings respectively in each patient. These 20 epochs were averaged into a single spike. The current dipole sources of the averaged spike were analyzed and located on a spherical head model. The current source density of the negative peak point of the averaged spike was located on the Talairach human brain map.
Results: The current dipole sources were in the right subcallosal gyrus, or the right or left anterior cingulate gyri. The current source density was distributed in the bilateral medial frontal area including the anterior cingulate gyri.
Conclusions: The interictal spikes of patients with gelastic epilepsy-hypothalamic hamartoma syndrome may be generated by the current sources located in the bilateral medial frontal area. Key Words: Gelastic seizure, Hypothalamic hamartoma, Current source analysis