Association Between Obstructive Sleep Apnea and Cardiovascular Diseases

J Korean Neurol Assoc > Volume 27(3); 2009 > Article

Journal of the Korean Neurological Association 2009;27(3): 223-228.

폐쇄수면무호흡증과 심혈관 질환 관련성 연구

김소현, 지기환 윤창호 하충건

인하대학교 의과대학 신경과학교실

Association Between Obstructive Sleep Apnea and Cardiovascular Diseases

So-Hyun Kim

Department of Neurology, Inha University Hospital, Incheon, Korea

Abstract

Background: Obstructive sleep apnea (OSA) contributes to the development of cardiovascular diseases. The aim of this study is to analyze the association between OSA and cardiovascular diseases in adult.
Methods: We recruited 718 consecutive subjects (611 male, 44.8±12.7 years old) diagnosed as OSA based on overnight polysomnography. The prevalence of hypertension, diabetes mellitus, myocardial infarction and stroke was defined and compared with that in general adult population (the Third Korea National Health and Nutritional Examination Survey, KNHANES III 2005). Correlation between the prevalence and OSA severity was analyzed after adjusting age, sex, body mass index, smoking, and alcohol consumption.
Results: Prevalence of vascular diseases was higher in OSA than general population. Prevalence of hypertension was 39.0% (13.0% from KNHANES III), diabetes 8.2% (5.2%), myocardial infarction 3.0% (0.6%) and stroke 7.2% (1.6%). Apnea-hypopnea index as the marker of OSA severity significantly correlated with hypertension (p=0.01).
Conclusions: Cardiovascular diseases were more prevalent in OSA. Prevalence of hypertension increased proportionally to OSA severity.Key Words: Sleep, Respiration, Hypertension