Four Cases of Probable Creutzfeldt-Jacob Disease with High Signals in Cerebral Cortex on Diffusion Weighted MR Imaging

J Korean Neurol Assoc > Volume 24(6); 2006 > Article

Journal of the Korean Neurological Association 2006;24(6): 596-600.

확산강조 뇌자기공명영상에서 대뇌 피질 고영상 병변을 보이는 임상적으로 진단된 크로이츠펠트-야콥병 4예

곽용태, 방오영a 김옥준b 김원주c

효자병원 신경과, 아주대학교 의과대학 신경과학교실a, 포천중문의과대학교 신경과학교실b, 연세대학교 의과대학 신경과학교실

Four Cases of Probable Creutzfeldt-Jacob Disease with High Signals in Cerebral Cortex on Diffusion Weighted MR Imaging

Yong Tae Kwak

Department of Neurology, Hyoja Geriatric Hospital, Yongin; Department of Neurology, Ajou University College of Medicinea, Suwon; Department of Neurology, Pochon CHA University College of Medicineb, Seongnam; Departments of Neurology, Yonsei University College of Medicinec, Seoul, Korea

Abstract

A high signal in the cerebral cortex and/or basal ganglia on a diffusion-weighted MRI (DWI) has been described as a good diagnostic marker for sporadic Creutzfeldt-Jakob disease (sCJD). We report four cases of sCJD with atypical clinical presentations and ribbon-like areas of high signals in the cerebral cortex on DWI. DWI patterns of asymmetric cortical high signals in the cerebral cortex may offer the means for diagnosis of sCJD early in the course of the illness even when the clinical presentations are atypical. KeyWords:Diffusion-weighted MRI, Creutzfeldt-Jakob disease, Cortical high signals