Two Cases of Metronidazole-Induced Neurotoxicity Lacking of Clinico- Radiological Correlation

J Korean Neurol Assoc > Volume 24(6); 2006 > Article

Journal of the Korean Neurological Association 2006;24(6): 581-584.

Metronidazole 중독증: 임상-신경영상 소견의 불일치를 보인 2예

권겸일, 이대균 이가현 조경희 이유진 정선주

울산대학교 의과대학 신경과학교실

Two Cases of Metronidazole-Induced Neurotoxicity Lacking of Clinico- Radiological Correlation

Kyum-Yil Kwon

Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea

Abstract

Metronidazole is an antimicrobial agent widely used for the treatment of trichomoniasis, giardiasis, amebiasis, and anaerobic bacterial infections. It has been reported that metronidazole-induced neurotoxicity is associated with responsible lesions on brain MRI. We report 2 patients with metronidazole-induced neurotoxicity, who had no responsible lesions on brain MRI for their neurological deficits. The pathogenic mechanisms are discussed.KeyWords:Metronidazole, Neurotoxicity, Brain MRI