Chronic Inflammatory Demyelinating Polyneuropathy Developed during Interferon-β Therapy in a Patient with Multiple Sclerosis

J Korean Neurol Assoc > Volume 24(5); 2006 > Article

Journal of the Korean Neurological Association 2006;24(5): 486-490.

Interferon-β를 사용하던 다발성경화증 환자에서 발생한 만성 염증성 탈수초성 다발성 신경병증

이찬녕, 김병조 박건우 고성범 김호정 이대희

고려대학교 의과대학 신경과학교실

Chronic Inflammatory Demyelinating Polyneuropathy Developed during Interferon-β Therapy in a Patient with Multiple Sclerosis

Chan-Nyoung Lee

Department of Neurology, Korea University College of Medicine, Seoul, Korea

Abstract

Preliminary studies have evaluated the effects of interferonβ formulations in the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP) because of pathogenic similarities between CIDP and multiple sclerosis (MS). However, the efficacy of Interferon, which has been widely used for relapsing-remitting MS, is controversial in CIDP. We report here a 31year old woman with relapsing-remitting type MS treated with IFNβ-1b over 2 years who developed overt CIDP. She responded favorably to steroids. This case suggests that IFNβ-1b treatment may not prevent development of CIDP.KeyWords:Multiple sclerosis, Chronic inflammatory demyelinating polyneuropathy, IFNβ