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J Korean Neurol Assoc > Volume 24(2); 2006 > Article
Journal of the Korean Neurological Association 2006;24(2): 125-130.
저산소성 뇌손상 후 발생한 급성 간대성근경련간질중첩증을 치료하기 위한 집중적 항경련제 투여는 필요한가?
최휘철, 송홍기
한림대학교 의과대학 신경과학교실
Is the Intensive Anticonvulsant Treatment for Control of Acute Posthypoxic Myoclonic Status Epilepticus Necessary?
Hui-Chul Choi, M.D.
Department of Neurology, Hallym university College of Medicine, Seoul, Korea
Abstract
Background: Acute posthypoxic myoclonic seizure is not an uncommon presentation in clinical practices. However, there have been only a few reports which include detailed description on the treatment of acute posthypoxic myoclonic status.
Methods: We retrospectively analyzed the etiology, clinical course, nature and duration of myoclonus after hypoxic brain damage during a ten year period from 1992 to 2002. Patients who had possible explanations for myoclonic seizure other than hypoxic-ischemic events were excluded.
Results: Eighty-two patients aged 24 to 81 years old were included in this study. All but 3 patients with pulmonary edema had a history of cardiorespiratory arrest caused by probable cardiogenic origin, acute asthma attack and upper airway obstruction. Ictal EEGs demonstrated intermittent generalized spike and polyspike activities or biPLEDs. Most patients died within a week and 6 patients remained in persistent vegetative states. The clinical outcome was not affected by the drug response of myoclonic status epilepticus or etiology of hypoxia.
Conclusions: Posthypoxic myoclonic status reflects severe and diffuse cortical damage, and implies a very poor prognosis. It may be a transient manifestation of severe cortical damage before massive and irreversible neocortical neuronal death, and aggressive anticonvulsant drug treatment would not be necessary in most patients.KeyWords:Hypoxia, Acute posthypoxic myoclonus, Status epilepticus.
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