SPM Analysis of Changes in Cerebral Blood Flow in Alzheimer's Disease with Apathy

J Korean Neurol Assoc > Volume 22(5); 2004 > Article

Journal of the Korean Neurological Association 2004;22(5): 492-498.

무감동증을 동반한 알쯔하이머병에서 국소뇌혈류 변화의 SPM 분석

강현욱, 박미영 이승현 이윤경 천경아

영남대학교 의과대학 신경과학교실, 핵의학교실

SPM Analysis of Changes in Cerebral Blood Flow in Alzheimer's Disease with Apathy

Hyun Uk Kang

Departments of Neurology, Neclear Medicine*, Yeungnam University College of Medicine, Daegu, Korea

Abstract

Background: Apathy is one of the most frequent behavioral symptoms in Alzheimer's disease (AD) and interferes with activities of daily living. The purpose of this study was to evaluate the differences of cerebral blood flow between AD without apathy and with apathy.
Methods: Nineteen AD patients without apathy (AD-NA group) and 15 AD patients with apathy (AD-A group) were evaluated. Cerebral perfusion was measured by 99mTc-ECD single photon emission computed tomography (SPECT). The images of the AD-A and AD-NA groups were statistically analysed by means of statistical parametric mapping (SPM) 99.
Results: Compared with AD-NA group, the AD-A group had significantly lower perfusion in the left inferior frontal regions (left orbital gyrus, Broadmann area 47 and left median frontal gyrus, Broadmann area 11) (uncorrected p<0.01).
Conclusions: These results suggest apathy may be related with disturbances in projections of frontal subcortical circuits, even though apathy is primarily related with dysfunction of the cingulate gyrus. Key Words: Apathy, Alzheimer's disease, SPECT, SPM