Statin Reduced the Platelet CD63 and CD40L Expression in Atherosclerotic Ischemic Stroke with Hyperlipidemia

J Korean Neurol Assoc > Volume 22(5); 2004 > Article

Journal of the Korean Neurological Association 2004;22(5): 453-458.

고지혈증을 가진 뇌경색 환자에서 Statin에 의한 혈소판의 CD63과 CD40L의 발현의 억제

이경미, 조월순 정민호 임영진 박귀선 차재관

동아대학교 의과대학 의과학연구소, 동아대학교 자연과학대학 식품영양학과교실

Statin Reduced the Platelet CD63 and CD40L Expression in Atherosclerotic Ischemic Stroke with Hyperlipidemia

Kyeong-Mi Lee

Clinical Institute of Medical Science, Dong-A University College of Medicine, Busan; Food Science and Nutrition, Dong-A University College of Natural Science*, Busan, Korea

Abstract

Background: Statin (HMG-coA-reductase inhibitor) has been known to protect vessels from atherothrombosis through various mechanisms. In this study, we evaluated the effects of statin on reducing the platelet expressions of CD63 and CD40 ligand (CD40L) in subjects with atherosclerotic ischemic stroke.
Methods: Twenty-one patients (17 men, 4 women; mean age 59.0±10.2 years) with atherosclerotic ischemic stroke were recruited. They took simvastatin 20 mg per day for 90 days and discontinued for another 90 days. We studied the changes of platelet expressions of CD63 and CD40L in all the patients after the use and discontinuance of simvastatin using whole blood flow cytometry.
Results: After taking simvastatin 20mg for 90 days, the serum concentrations of L이 cholesterol decreased significantly (96.4±31.4 mg/dL, p<0.001) compared with those at the baseline (158.8±25.0 mg/dL). The platelet CD63 and C40L expressions were also significantly reduced by treatment of simvastatin 20 mg for 12 weeks (p<0.05). However, the effects of statin on CD63 and CD40L expressions disappeared after 12 weeks of cessation. Furthermore, changes of expressions of CD63 and CD40L by statin did not correlate with its cholesterol lowering effect (r=-0.311, p=0.386).
Conclusions: This study demonstrates that the use of statin may be a helpful strategy to regulate the platelet activation in patients with atherosclerotic ischemic stroke. Key Words: Statin, Blood Platelet, Inflammation