Anti-Hu Antibody Associated Sensory Neuronopathy Accompanied 
by Autonomic Dysfunction

J Korean Neurol Assoc > Volume 22(3); 2004 > Article

Journal of the Korean Neurological Association 2004;22(3): 272-275.

자율신경부전을 동반한 Anti-Hu 항체 양성의 감각신경원병증

박영은, 주환 김대성 정대수 박규현 이민기

부산대학교 의과대학 신경과학교실, 내과학교실

Anti-Hu Antibody Associated Sensory Neuronopathy Accompanied by Autonomic Dysfunction

Young-Eun Park

Departments of Neurology and Internal Medicine*, Pusan National College of Medicine, University

Abstract

Paraneoplastic sensory neuronopathy may present with autonomic dysfunction resulting either from autonomic neuropathy, or invasion/compression by tumor. We present a 61-year-old female presented with frequent syncope, anhidrosis, and sensory change. Investigations disclosed sensory-autonomic polyneuropathy with positive anti-Hu antibody. The chest computed tomography showed a left mediastinal mass with invasion to the brachiocephalic vein, and a small cell lung cancer was confirmed. She was treated with radiation therapy showing limited improvement. The possible causes of autonomic dysfunction in our patient were discussed.Key Words:Paraneoplastic polyneuropathy, Autonomic nervous system, Small cell carcinoma