Ataxic Variant of Guillain-Barre Syndrome Associated with 
Anti-GD1b Ig G Antibody

J Korean Neurol Assoc > Volume 22(3); 2004 > Article

Journal of the Korean Neurological Association 2004;22(3): 269-271.

항 GD1b Ig G 항체와 연관된 실조형 길랑-바레증후군 1예

배종석, 윤동주 김민기 김병준

지방공사 강남병원 신경과, 성균관대학교 의과대학 신경과학교실

Ataxic Variant of Guillain-Barre Syndrome Associated with Anti-GD1b Ig G Antibody

Jong-Seok Bae

Department of Neurology, Kangnam General Hospital Public Corporation, Seoul; Department of Neurology, Sungkyunkwan University School of Medicine*, Seoul, Korea

Abstract

It is known that anti GD1b antibody bind to the cerebellar granular layer or spinocerebellar Ia fiber. We recently encountered a patient of Guillain Barr syndrome (GBS) showing marked cerebellar ataxia and relatively mild quadriparesis but completely intact extraocular eye movement. Markedly high IgG anti GD1b antibody titer was identified from the patient's serum. The nerve conduction study showed reduction of compound muscle action potential without evidence of perpheral nerve demyelination. We report an ataxic variat of GBS associated with anti GD1b IgG antibody.Key Words:Guillain-Barre syndrome, Cerebellar ataxia, Autoantibody, Anti GD1b