The Change of Cerebral Metabolites in Patients with Parkinson's Disease Measured by Proton Magnetic Resonance Spectroscopy

J Korean Neurol Assoc > Volume 21(6); 2003 > Article

Journal of the Korean Neurological Association 2003;21(6): 622-627.

뇌 자기공명분광법으로 측정한 파킨슨병 환자의 뇌 대사물질 변화

김종기 , 김병채 이기라 송민경 박만석 김명규 조기현 서정진

전남대학교 의과대학 신경과학교실, 방사선과학교실*, 전남대학교 의과학연구소

The Change of Cerebral Metabolites in Patients with Parkinson's Disease Measured by Proton Magnetic Resonance Spectroscopy

Jong-Ki Kim

"Department of Neurology and Radiology*, Chonnam National University Medical School and Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea"

Abstract

Background: Parkinson's disease is a progressive, common neuro-degenerative disorder of the extrapyramidal system leading to specific motor symptoms, but there is no specific early diagnostic tool. This study was aimed to investigate the change of cerebral metabolites in patients with parkinson's disease by 1H magnetic resonance spectroscopy (MRS).
Methods: Eighteen patients with idiopathic unilateral symptomatic parkinson's disease underwent MRS study to compare metabolites of basal ganglia and thalamus, in ipsilateral and contralateral to the clinically affected side.
Results: In patients with unilateral symptomatic parkinson's disease, N-acetyl aspartate (NAA)/Creatine (Cr) ratio was significantly lower in contralateral side to the clinically affected side than in ipsilateral side (p=0.023). Other cerebral metabolites (Cho, mI, α- Glx, β-Glx, lactate, lipid) were showed no significant difference in patients with parkinson's disease.
Conclusions: The comparison and quantification of cerebral metabolites by using MRS may be helpful to diagnosis and investigation of parkinson's disease.Key Words: Parkinson's disease, Magnetic resonance spectroscopy (MRS)