J Korean Neurol Assoc > Volume 21(4); 2003 > Article

Journal of the Korean Neurological Association 2003;21(4): 372-377.

"새롭게 진단된 부분간질 환자에서 발작의 재발에 대한 2년간의 전향적 조사: 뇌 자기공명영상이 발작의 재발을 예측할 수 있는가?"

장철원 , 강태홍 김상진 김성은 김정호*

인제대학교 의과대학 부산백병원 신경과학교실, 예방의학교실*

"Two-year Prospective Study of Seizure Recurrence in Newly Diagnosed Partial Epilepsy: Can MRI Predict the Recurrence of Seizure?"

Cheol-Won Jang

Department of Neurology, Department of Preventive Medicine*, Inje University, Pusan Paik Hospital

Abstract

"Background: It has been known that several factors are associated with seizure recurrence. We performed this study to determine whether an MRI can independently predict seizure recurrence in newly diagnosed partial epilepsy.
Methods: We found 91 newly diagnosed partial epilepsy patients with whom we prospectively followed up for at least 2 years. Variables for statistical analysis were cumulative recurrence rates according to MRI findings as well as age of onset, etiology and epilepsy syndrome. We divided MRI findings into paired groups of normal and abnormal groups, age of onset into .27 years and .28 years groups, etiology into symptomatic and cryptogenic groups and epilepsy syndrome into temporal lobe epilepsy and extratemporal lobe epilepsy groups respectively.
Results: The seizure recurrence rate was 24% at 1 year and 36% at 2 years follow-up. Among prognostic variables, the epilepsy syndrome, etiology and MRI findings could significantly predict the seizure recurrence at 2 years but age of onset could not predict recurrence at 2 years follow-up. Univariate analysis showed the odds ratio of the seizure recurrence as follows: temporal lobe epilepsy was 1.91 (95%CI 0.89~4.12), symptomatic etiology was 2.27 (95%CI 1.13~4.57), abnormal MRI finding was 2.80 (1.40~5.60). Multivariate analyses showed that only abnormal MRI findings could independently predict the seizure recurrence.
Conclusions: We conclude that abnormal MRI finding can independently predict seizure recurrence at 2 years follow-up. Key Words: Recurrence, Magnetic resonance imaging, Epilepsies/Partial"