J Korean Neurol Assoc > Volume 21(4); 2003 > Article

Journal of the Korean Neurological Association 2003;21(4): 357-363.

알쯔하이머병에서 일상생활능력의 정도와 임상 양상과의 연관성

김태유 , 권오영 김상윤 최낙천 임병훈

부산동인노인병원 신경과, 경상대학교 신경과학교실, 서울대학교 신경과학교실

"The Relationship between the Degree of Activity of Daily Living and Clinical Features in Alzheimer■s Disease"

Tae-You Kim

"Department of Neurology, Dongin Geriatric Hospital, Busan, Korea Department of Neurology, Gyeongsang National University College of Medicine*, Jinju, Korea Department of Neurology, Seoul National University College of Medicine†, Seoul, Korea"

Abstract

"Background: The limitation of activities of daily living (A이) is a critical problem in dementia patients in addition to cognitive dysfunction. In spite of many previous studies about the relationship between cognitive dysfunction, A이 and the nature of functional changes, there have not been any clear explanations about the liaisons between them due to various results from the diversity of objects and methods. The purpose of this study is to evaluate the relationship between ADL and clinical features in patients with Alzheimer s disease. M e t h o d s: One hundred thirty-four patients with Alzheimer s disease were enrolled to participate in the study. The physical activity of daily living (P-ADL) and the Korean instrumental activity of daily living (K-IADL) were evaluated in the patients. In addition, all subjects were tested by a Korean version of the expanded clinical dementia rating scale (CDR), and a Korean version of the mini-mental state examination (K-MMSE) and a Korean version of the neuropsychiatric inventory (NPI).
Results: ADL was significantly correlated with cognitive functioning (r>-0.75, p<0.01). NPI was not significantly correlated with P-ADL and KIADL. The ability to use the telephone was the most highly correlated with CDR and K-MMSE (r>0.72, p<0.01). The ability to use the telephone was the most predictable item in K-IADL and bathing was the most predictable item in PADL. The deterioration of K-IADL showed rapid progression in the degree of CDR 2 and P-ADL showed rapid progression in the degree of CDR 4, respectively.
Conclusions: The ADL decline induced by dementia may progress and have a close correlation with clinical manifestations of dementia including cognitive dysfunction, behavioral symptoms and psychological symptoms. Key Words: Alzheimer s disease, Dementia, Physical activity of daily living, Korean instrumental activity of daily living"