J Korean Neurol Assoc > Volume 21(2); 2003 > Article

Journal of the Korean Neurological Association 2003;21(2): 210-212.

우발적 뇌척수강 내 V I n c r i s t i n e 주입에 의한 뇌척수신경병증

김돈수 , 김용덕 유철우

건양대학교 의과대학 신경과학교실,을지대학교 의과대학 소아과학교실

"Neuromyeloencephalopathy Induced by Inadvertent Intrathecal Vincristine Injection"

Don-Soo Kim

"Department of Neurology, College of Medicine, Konyang University Department of Pediatrics, College of Medicine, Eulji University"

Abstract

"Accidental intrathecal vincristine instillation is extremely toxic to the central nervous system. If given intrathecally, it produces a rapidly ascending, usually fatal, neuromyeloencephalopathy. This is a case where a 10-year-old girl received an inadvertent intrathecal administration of vincristine. The clinical course was rapidly progressive and resulted in comatose and vegetative state. Magnetic resornance image at post-injection 11 day showed high signal intensity lesion in cerebellar hemisphere and vermis adjacent to CSF passage third and fourth ventricle on T2 weighted images.Key Words : Intrathecal vincristine, Neuromyeloencephalopathy, Acute lymphoblastic leukemia"