Relationships of Apolipoprotein E Genotypes with Vascular Risk Factors in Patients with Alzheimers Disease

J Korean Neurol Assoc > Volume 21(1); 2003 > Article

Journal of the Korean Neurological Association 2003;21(1): 41-45.

알쯔하이머병 환자에서 아포지단백E 유전자형과 혈관성 위험인자와의 관계

손의주, 김재민 김요식 김병채 김명규 조기현

상무병원 신경과,조선대학교 의과대학 정신과학교실*,원광대학교 의과대학 신경과학교실, 전남대학교 의과대학 신경과학교실

Relationships of Apolipoprotein E Genotypes with Vascular Risk Factors in Patients with Alzheimers Disease

Eui Ju Son

"Department of Neurology, Sangmoo Hospital, Department of Psychiatry, Chosun University College of Medicine*, Department of Neurology, Wonkwang University Medical School †, and Department of Neurology, Chonnam National University Medical School"

Abstract

"Background : Apolipoprotein E-epsilon4 (APOE-ε4) is a known genetic risk factor for Alzheimer ?s disease (AD), but its relationship with vascular risk factors is still controversial. Methods : We retrospectively studied 56 probable AD patients diagnosed by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer s Disease and Related Disorder s Association (NINCDS-ADRDA) criteria. Results : The frequencies of APOE-ε2, 3, and 4 were 6.3%, 69.6%, and 24.1% in patients with AD. Compared to the no APOE-ε4 group (n=35), the APOE-ε4 group (n=21) revealed a higher frequency of male gender with no difference in age, educational level, dementia onset age, severity of dementia (CDR and K-MMSE), the frequencies of vascular risk factors (hypertension, diabetes, hypercholesterolemia), and total cholesterol level. High density lipoprotein (HDL)-cholesterol level was 36 ± 8 in the APOE-ε4 group and 43 ±11 in the no APOE-ε4 group with statistical significance (Student ?s t-test, p=0.02). In adjusting for sex, the APOE-ε4 group still had a significantly lower HDL-cholesterol level than the no APOE-ε4 group (p=0.047). Conclusions : These results suggest that there may be the genetic influence of APOE-ε4 on serum HDL-cholesterol metabolism in AD patients.Key Words : Dementia, Alzheimer　s disease, Apolipoprotein E, Cholesterol"