Three Cases of Ticlopidine-induced Cholestatic Hepatitis

J Korean Neurol Assoc > Volume 20(4); 2002 > Article

Journal of the Korean Neurological Association 2002;20(4): 434-436.

Ticlopidine 복용으로 유발된 담즙정체성 간염 3예

김지현, 권영주 김정은 우가은 김용재

이화여자대학교 의과대학 신경과학교실,내과학교실

Three Cases of Ticlopidine-induced Cholestatic Hepatitis

Jee-Hyun Kim

Department of Neurology, Department of Internal Medicine, Ewha Womans University Hospital

Abstract

"Ticlopidine hydrochloride is world-wide used antiplatelet agent that inhibit ADP pathway. Its clinical side effects are the change of the blood picture, allergic skin reaction and gastrointestinal symptoms. We report three patients with severe cholestatic hepatitis caused by ticlopidine. They developed jaundice about 20days after taking ticlopidine (500 mg/day). Infectious and immunological etiologies were excluded by serology. There was no history of alcohol or drug abuse. Their symptoms were gradually subsided for a few months after discontinuing ticlopidine. Key Word : Ticlopidine, Cholestatic hepatitis"