J Korean Neurol Assoc > Volume 20(4); 2002 > Article

Journal of the Korean Neurological Association 2002;20(4): 353-358.

"한국판 Neuropsychiatric Inventory로 분석한 피질하 혈관성치매와 알쯔하이머병의 행동장애 패턴의 차이"

고석범, 양동원 정성우 최영빈 김범색

가톨릭대학교 의과대학 신경과학교실

"The Different Patterns of Behavioral Derangements in Subcortical Vascular Dementia and Alzheimer ’s Disease - Evaluated by the Korean Version of the Neuropsychiatric Inventory-"

"Seok Beum Koh"

Department of Neurology, College of Medicine, The Catholic University of Korea

Abstract

"Background : The neuropsychiatric derangements in dementing patients are common and troublesome in their man-agements. The purpose of this study is to compare the behavioral changes in patients with subcortical vascular dementia (SVaD) and to those in patients with Alzheimer ’s disease (AD) by using the Korean version of the neuropsychiatric inventory (K-NPI). Methods : The K-NPI was administrated to the close caregivers of 19 patients with AD (who met the criteria of the NINCDS-ADRDA for probable AD) and 14 patients with SvaD (who met the criteria of the NINDS-AIREN criteria for probable or possible VaD). Groups were matched for age, education and dementia severity. We evaluated the prevalence, the composite score (frequency ×severity) of each behavioral domain in K-NPI between two groups. Results : The most common behavioral disturbances were anxiety (63%) in AD and apathy/indifference (93%) in SVaD. Patients with SVaD had significantly greater total K-NPI scores than patients with AD and exhibited apathy/indifference, agitation/aggression and anxiety more frequently. Composite score of apathy/indifference over 4.7 point discriminates between AD and SVaD with accuracy of 75.8%. Conclusions : The K-NPI provides behavioral pro-files that differentiate patients with SVaD from patients with AD. Patients with SVaD are more behaviorally disturbed. Clinicians need to pay more attention to the behavioral disturbances when managing the patients with SVaD.Key Words : Alzheimer ’s disease, Subcortical vascular dementia, Neuropsychiatric inventory."