Two Cases of Simvastatin-induced Acute Myopathy

J Korean Neurol Assoc > Volume 19(4); 2001 > Article

Journal of the Korean Neurological Association 2001;19(4): 435-437.

Simvastatin에 의한 급성 근병증을 보인 2예

김승민, 오윤민 선우일남 박기종*

연세대학교 의과대학 신경과학교실,경상대학교 의과대학 신경과*

Two Cases of Simvastatin-induced Acute Myopathy

Seung Min Kim, M.D., Youn Min Oh, M.D., Il-Nam Sunwoo, M.D., Ki-Jong Park, M.D.*

"Department of Neurology, Yonsei University Medical College Department of Neurology, College of Medicine, Gyeongsang National University*"

Abstract

"Among the side effects of simvastatin, elevated liver enzyme or creatine kinase activity has been occasionally report-ed, but overt myopathy is rare. We report two cases of simvastatin-induced myopathy with usual dosages of simvas-tatin. Two patients presented with general myalgia, markedly elevated creatine kinase activity, and mild proximal weak-ness. One patient had been treated with concomitant use of cyclosporine and simvastatin after renal transplantation, and another patient had diabetic nephropathy. We recommend careful monitoring when myalgia appears in a patient receiv-ing simvastatin. J Korean Neurol Assoc 19(4):435~437, 2001 Key Words : Simvastatin, Myopathy, Cyclosporine"