Neurologic Complications of Infective Endocarditis:Retrospective Review of 100 Cases

J Korean Neurol Assoc > Volume 19(3); 2001 > Article

Journal of the Korean Neurological Association 2001;19(3): 202-206.

감염성 심내막염의 신경계 합병증:후향적 분석 1 0 0예

김성훈, 구자성*윤병우†

강원대학교 의과대학 신경과학교실,을지의과대학교 을지병원 신경과학교실*서울대학교 의과대학 신경과학교실†

Neurologic Complications of Infective Endocarditis:Retrospective Review of 100 Cases

Sung Hun Kim, M.D., Jaseong Koo, M.D.*, Byung-Woo Yoon, M.D.†

"Department of Neurology, Kangwon National University Hospital Department of Neurology , Eulji University School of Medicine, Eulji Hospital* Department of Neurology, Seoul National University Hospital†"

Abstract

"Background : Neurological syndromes often complicate the management of infective endocarditis. Methods : We reviewed the neurological complications in 100 patients with infective endocarditis in a tertiary care hospital. Results : Neurological complications occurred in 25 patients (25%). Ischemic infarctions occurred in 15 patients, hemorrhagic infarctions in 5, intracerebral hemorrhages in 12, subarachnoid hemorrhages in 4, and subdural hemorrhages in 2. Brain abscess was detected in 4 and seizures in 2 patients. Staphylococcus aureus endocarditis (p=0.01) and mitral valvular heart disease (p=0.015) correlated statistically with the development of neurological complications. The mortality rate was significantly higher in patients with neurological complications than those without neurological complications (p=0.00). Age, sex, and type of valve (native versus prosthetic) were not related to the complication rate. Conclusions : We concluded that (1) hemorrhagic complications occurred at a higher rate in this study than previous reports; (2) S.aureus infection and mitral valvular disease predicted the occurrence of neurological complications; and (3) neurolog-ical complications were related to mortality rates. J Korean Neurol Assoc 19(3):202~206, 2001 Key Words : Infective endocarditis, Neurological complication, Heart disease"