Dysarthria after Donepezil

J Korean Neurol Assoc > Volume 19(2); 2001 > Article

Journal of the Korean Neurological Association 2001;19(2): 170-172.

Donepezil 복용 후 발생한 구음장애

정산, 백종삼

경기도립 노인전문병원 신경과

Dysarthria after Donepezil

San Jung, M.D., Jong Sam Baik M.D.

Department of Neurology, Kyunggi Provincial Hospital For The Elderly

Abstract

"We report a case of speech disturbance as an unrecognized adverse effect of the selective acetylcholinesterase inhibitor, donepezil. A 79-year-old woman presented with progressive memory disturbance that began 3 years ago. A brain MRI and neuropsychological test suggested that she had Alzheimer’s disease. She showed transient dysarthria 14 days after the initiation of donepezil. Isolated speech disturbances were not observed. Clinicians should be alert to the possibility of dysarthria as an adverse effect of donepezil. J Korean Neurol Assoc 19(2):170~172, 2001 Key Words : Alzheimer’s disease, Donepezil, Dysarthria"