| 편두통의 임상 양상과 경두개 초음파검사상이상 소견과의 연관성 |
| 홍삼남, 김병건 ·구자성 ·이용석*·배희준 |
| 을지의과대학 을지병원 신경과,서울특별시립 보라매병원 신경과* |
| Clinical Correlation of Abnormal Transcranial Doppler in Migraineurs |
| Sam-Nam Hong, M.D., Byung-Kun Kim, M.D., Ja-Seong Koo, M.D.,Yong-Seok Lee, M.D.*, Hee-Joon Bae, M.D. |
| Department of Neurology, Eulji General Hospital, Eulji University School of MedicineDepartment of Neurology, Seoul Municipal Boramae Hospital* |
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| Abstract |
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Background : It is well-known that migraineurs frequently have abnormal findings on transcranial Doppler ultra-sound (TCD), but their clinical implications are not clear. We investigated the clinical significance of TCD findings in migraineurs. Methods : One hundred thirty-seven consecutive migraineurs were prospectively gathered. The following clinical parameters were investigated : 1) age and sex, 2) time from onset of headache to visiting hospital, 3) frequency, duration, laterality, pulsating quality, and severity of headache, 4) presence of nausea, vomiting, photophobia, and phonophobia, 5) aura, and 6) aggravation of headache by routine physical activity. TCD was performed during a headache-free period to measure the mean flow velocities (MFVs) and other parameters of 13 intracranial and 2 extracranial vessels. If MFV of any artery or its side-to-side difference in each migraineur was beyond 2 standard devia-tions of corresponding age and sex-matched reference subgroups, the TCD result was regarded as abnormal. Correlations between abnormal TCD and clinical parameters were examined by univariate and multivariate analyses. Results : Results of TCD were abnormal in 84 patients (61.3%). Pulsatility of headache and absence of aura were sig-nificantly correlated with abnormal TCD on univariate analyses (p=0.003 and 0.049 respectively). On multivariate analysis, pulsatility of headache was the only statistically significant predictor of abnormal TCD (p=0.015). Headache attacks tended to be less frequent in patients with abnormal TCD with marginal significance (p=0.050). Conclusions : Our study shows that abnormal results on TCD are more frequent in migraineurs with pulsatile headache. An associa-tion between abnormal TCD and frequency of headache attacks is suggested.J Korean Neurol Assoc 18(6):711~715, 2000Key Words : Headache, Migraine, Transcranial doppler |
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