A Case of Osteomalacic Myopathy

J Korean Neurol Assoc > Volume 18(5); 2000 > Article

Journal of the Korean Neurological Association 2000;18(5): 669-671.

골연화성 근병증 1예

최성호, ·홍석경 ·김재우

동아대학교 의과대학 신경과학교실

A Case of Osteomalacic Myopathy

Seung Ho Choi, M.D., Suk Kyung Hong, M.D., Jae Woo Kim, M.D.

Department of Neurology, College of Medicine, Dong-A University

Abstract

Osteomalacia is a disorder in which the mineralization of the organic matrix of the skeleton is defective. Proximal mus-cular weakness is a common symptom of osteomalacia. A 27-year-old woman reported the gradual onset of gait distur-bance and bone pain in the thigh. Her height shortened during 10 months. On neurological examinations, proximal muscu-lar weakness of the extremities was disclosed. Serum phosphorus was 1.8 mg/dl (normal 2.5~4.5), alkaline phosphatase was 1045 IU/L (normal 70~290), and 1,25 (OH)2 vitamin D3 was 18 pg/ml (normal 20~60). On roentgenography, multiple pseudofracture lines of the rib and erosion of the head of the right femur were demonstrated. A bone scan showed multiple hot spots on the ribs and right femur. She was medicated with calcitriol and phosphorus and she recovered most of her strength and experienced decreased bone pain after 3 months. We report a case that confirms osteomalacic myopathy by an endocrinological test in patients who experienced gradual proximal muscular weakness and bone pain. J Korean Neurol Assoc 18(5):669~671, 2000 Key Words : Osteomalacia, Myopathy, Vitamin D3, Bone pain