Cerebral Venous Sinus Thrombosis Associated with
Antithrombin III Deficiency : A Case Report

J Korean Neurol Assoc > Volume 18(5); 2000 > Article

Journal of the Korean Neurological Association 2000;18(5): 637-641.

안티트롬빈 III 결핍과 연관된 대뇌정맥동 혈전증 1예

김종철, 강석윤 송현석 이상암

울산대학교 의과대학 서울중앙병원 신경과학교실

Cerebral Venous Sinus Thrombosis Associated with Antithrombin III Deficiency : A Case Report

Jong-Chul Kim, M.D., Suk-Yun Kang, M.D., Hyun-Seok Song, M.D., Sang-Ahm Lee, M.D.

Department of Neurology, Asan Medical Center, College of Medicine Ulsan University

Abstract

Antithrombin III deficient individuals have an increased risk of venous thrombosis and thromboembolism at a young age. To our knowledge, cerebral venous thrombosis associated with antithrombin III deficiency has not yet been report-ed in Korea. A 27-year-old pregnant woman without any known stroke risk factors was admitted to our hospital because of convulsions. Brain MRI and MR venography showed dural sinus thrombosis of the superior sagittal sinus, straight sinus, and left lateral sinus with venous hemorrhagic infarctions in both frontal and parietal lobes. Antithrombin III con-centrations were decreased to 37%. We speculated that the etiology of the cerebral venous thrombosis in this patient was associated with antithrombin III deficiency. We suggest that antithrombin III deficiency should be considered as a possible cause of cerebral venous thrombosis. J Korean Neurol Assoc 18(5):637~641, 2000 Key Words : Cerebral venous thrombosis, Antithrombin III deficiency, Free protein S