Binswanger’s Disease Associated with Alzheimer’s Pathology: An Autopsy Case

J Korean Neurol Assoc > Volume 18(5); 2000 > Article

Journal of the Korean Neurological Association 2000;18(5): 632-636.

Alzheimer 병리소견을 동반한 Binswanger병 부검 1예

주성민, 김병기 이화영 김후원 오건세 송희정 양기화*김대홍†

을지의과대학교병원 신경과,병리과*,방사선과†

Binswanger’s Disease Associated with Alzheimer’s Pathology: An Autopsy Case

Seong-Min Ju, M.D., Byung-Gi Kim, M.D., Hwa-Young Lee, M.D., Hoo-Won Kim, M.D., Gun-Sei Oh, M.D., Hee-Jung Song, M.D., Ki-Hwa Yang, M.D.*, Tae-Hong Kim, M.D.†

Department of Neurology, Pathology* and Radiology† , Eulji University Hospital, Taejon, Korea

Abstract

Binswanger’s disease (BD) is an illness of hypertensive elderly patients characterised clinically by disorders of mem-ory, mood and cognition; focal motor signs; and less often, a pseudobulbar syndrome with deterioration of gait and sphincter control. The illness is usually slowly progressive. The important pathological features of BD are widespread degeneration in the deep white matter with diffuse, patchy axonal and myelin loss, and gliosis. The more diffuse lesions in the centrum semiovale have been related to myelin rarefaction that spares the U-fibers. The MRI appearance of BD is multiple confluent white matter lesions of various sizes, many of which are quite small and concentrated around the basal ganglia and periventricular areas. We report an autopsy case of Binswanger’s disease associated with Alzheimer’s pathology. J Korean Neurol Assoc 18(5):632~636, 2000 Key Words : Binswanger’s disease, Alzheimer’s disease