A Case of Thrombotic Thrombocytopenic Purpura Associated with Ticlopidine

J Korean Neurol Assoc > Volume 18(4); 2000 > Article

Journal of the Korean Neurological Association 2000;18(4): 512-514.

Ticlopidine을 복용한 후 발생한 혈전성 혈소판 감소성 자반증 1예

배명철, 김장욱 ·장은아*·허 균

아주대학교 의과대학 신경과학교실,임상병리학교실*

A Case of Thrombotic Thrombocytopenic Purpura Associated with Ticlopidine

Myung-Cheol Bae, M.D., Jang-Wook Kim, M.D., Eun-Ah Jang, M.D.*, Kyoon Huh, M.D.

Department of Neurology and Clinical Pathology*, Ajou University Hospital

Abstract

Ticlopidine, a widely used antiplatelet agent, has been rarely reported to cause thrombotic thrombocytopenic purpura (TTP). To the best of our knowledge, its occurrence has never before been reported in Korea. A 69 years old female patient suffered from an acute ischemic stroke. Ticlopidine 250mg bid was started and she followed an uneventful clin-ical course. The platelet count was normal on the 1st and the 12th day of ticlopidine administration. Around the 31st day, at home, she developed purpura, dyspnea and a stuporous mental status. Under the diagnosis of TTP, a plasma exchange was performed and her condition eventually returned to the baseline status. Ticlopidine induced TTP can developed abruptly despite close monitoring of platelet count, as illustrated by this case. Physicians prescribing ticlopi-dine should be aware of this potentially dangerous complication. J Korean Neurol Assoc 18(4):512~514, 2000 Key Words : Ticlopidine, Purpura/Thrombotic thrombocytopenic