An Deletion/Insertion Polymorphism of the Angiotensin Converting Enzyme Gene in Ischemic Stroke Patients

J Korean Neurol Assoc > Volume 18(3); 2000 > Article

Journal of the Korean Neurological Association 2000;18(3): 261-266.

허혈성 뇌졸중 환자에서 안지오텐신(Angiotensin) 전환효소 유전자의 다형성

최용민 최재철 한진규 박민규 박건우 이대희, 최용민 최재철 한진규 박민규 박건우 이대희

고려대학교 의과대학 신경과학교실

An Deletion/Insertion Polymorphism of the Angiotensin Converting Enzyme Gene in Ischemic Stroke Patients

Yongmin Choi, M.D., Jaychol Choi, M.D., Jinkyu Han, M.D., Min-Kyu Park, M.D., Kunwoo Park, M.D., Dae-Hie Lee, M.D.

Department of Neurology, Korea University College of Medicine

Abstract

B a c k g r o u n d : A deletion (D)/insertion (I) polymorphism of the angiotensin-converting enzyme (ACE) gene is known to be associated with hypertension, left ventricular hypertrophy, myocardial infarction. Cardiac diseases, such as atrial fibrillation, valvular heart disease, myocardiac infarction and coronary artery disease have been clearly associated with increasing the risk of ischemic stroke. We investigated the relationship between ACE gene deletion/insertion (D/I) polymorphism and the pattern of ischemic stroke. M e t h o d s : The pattern of ACE genotypes in 59 stroke patients including symptomatic carotid artery territory cerebral ischemia were compared with 101 age-matched control subjects. In the stroke patients, the degrees of stenosis of bilateral cervical carotid arteries and their major intracranial tributaries were recorded according to duplex neck sonography and magnetic resonance angiography. DNA was extracted from peripheral blood and ACE I/D polymorphism is confirmed by PCR method. Results : In the stroke patients, 25.4% showed the I I genotypes, 8.5% the ID genotypes and 66.1% the DD genotypes. In the control group, the frequencies of each genotype were 20.8%, 55.4% and 23.8%, respectively. The DD genotypes were more common in patients with ischemic stroke compared with the controls, but there was no significant association between ACE genotypes and sub-types of cerebrovascular disease. Conclusions : The deletion polymorphism in the angiotensin-converting enzyme gene may play a role in development of ischemic stroke. J Korean Neurol Assoc 18(3):261~266, 2000 Key Words : Cerebral infarction, Polymorphism (genetics), Polymerase chain reaction