The Serum Levels of Interleukin-8, Monocyte Chemoattractant Protein-1, and Macrophage Inflammatory Protein-1 αin Patients with Acute Ischemic Stroke and with Atherosclerosis

J Korean Neurol Assoc > Volume 18(2); 2000 > Article

Journal of the Korean Neurological Association 2000;18(2): 132-137.

Interleukin-8,Monocyte Chemoattractant Protein-1과 Macrophage Inflammatory Protein-1 α의 농도

차재관, 김상호이김재우

동아대학교 의과대학 신경과학교실

The Serum Levels of Interleukin-8, Monocyte Chemoattractant Protein-1, and Macrophage Inflammatory Protein-1 αin Patients with Acute Ischemic Stroke and with Atherosclerosis

Jae-Kwan Cha, M.D., Sang Ho Kim, M.D., Jae Woo Kim, M.D

Department of Neurology, College of Medicine, Dong-A University

Abstract

Background : Chemokines are molecules with chemotatic activities on selective leukocyte populations and are sub-grouped into α-chemokine acting primarily on PMNL (polymorphonuclear leukocyte) and β-chemokines attracting mainly lymphocytes and monocytes. We conducted a prospective study to investigate the serum levels of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1 αin patients with acute ischemic stroke and carotid atherosclerosis. Methods : Serum was sampled from patients with acute ischemic stroke (<24hrs), with persistent ischemic neurological deficits associated with atherosclerosis (>1 month), and from normal subjects without a history of vascular disease. Concentrations of chemokines were measured by enzyme linked immunosorbent assay (ELISA). R e s u l t s : Compared with carotid atherosclerotic patients and control subjects, the serum levels of IL-8 were significantly elevated in those with acute ischemic stroke. The serum levels of MCP-1 in patients with large artery disease were higher than those in patients with small vessel disease and cardioembolism. Conclusions : This study suggested that IL-8 can be involved in acute ischemic stroke and MCP-1 plays a role in the pathogenesis of atherosclerosis. J Korean Neurol Assoc 18(2):132~137, 2000 Key Words : Chemokines, Stroke, Atherosclerosis, Cytokines