Serum Neuron Specific Enolase in Vertiginous Patients

J Korean Neurol Assoc > Volume 16(4); 1998 > Article

Journal of the Korean Neurological Association 1998;16(4): 506-509.

현훈 환자에서 Neuron Specific Enolase의 임상적 의의

김원주, 김선곤 . 유철형. 김원찬 . 김용덕 . 최영철 . 이명식

연세대학교 의과대학 영동세브란스병원 신경과

Serum Neuron Specific Enolase in Vertiginous Patients

Won-Joo Kim, M.D., Sun-Kweon Kim, M.D., Chul-Hyoung Lyoo, M.D., Won-Chan Kim,M.D., Yong-Duk Kim, M.D., Young-Chul Choi, M.D., Myung-Sik Lee, M.D.

Department of Neurology, Youngdong Severance Hospital, Yonsei University, College of Medicine

Abstract

Background : Vertiginous sense means sensation of rotation. Many patients suffer from vertiginous sense and visit emergency room or clinics. It is important to differentiate the vertigo patients into peripheral type and central type, because central vertigo need urgent treatment. Neuron specific enolase (NSE) is a component of specific brain enzyme and consist of 1.5% of total brain protein and is a useful marker to detect brain injury. We evaluated the significance of NSE in vertiginous patients. Methods : We performed this test in acute vertiginous patients whose attack started within 24 hours. Neurological examination, MRI and vestibular function test were performed. By these results, ten peripheral type vertiginous patients and ten central type patients were selected. Results : The mean NSE level of control was 6.4 ±3.4 ng/ml, peripheral type patients was 7.6 ±2.8 ng/ml and central type was 12.0 ± 3.9 ng/ml. The central type patients group was significantly higher than other group (p<0.05). Conclusion : The Neuron specific enolase (NSE) level is significantly higher in central vertiginous patients group than peripheral group and control. NSE can be helpful method to differentiate central vertigo from peripheral one in acute phase. Key words : Neuron specific enolase - Vertigo - Central type - Peripheral type