A Case of Cytomegalovirus Lumbosacral Polyradiculopathy
in Acquired Immune Deficiency Syndrome

J Korean Neurol Assoc > Volume 16(3); 1998 > Article

Journal of the Korean Neurological Association 1998;16(3): 408-412.

후천성 면역결핍증 환자에서 발생한 CMV 요천추 다발성신경근병증 1례

조용진, 임용빈·김대성·정대수·박규현

부산대학교 의과대학 신경과학교실

A Case of Cytomegalovirus Lumbosacral Polyradiculopathy in Acquired Immune Deficiency Syndrome

Yong-Jin Jo, M.D., Yong-Bin Yim, M.D., Dae-Seong Kim, M.D., Dae-Soo Jung, M.D.and Kyu-Hyun Park, M.D.

Department of Neurology, Pusan National University Hospital

Abstract

Background & Significance : Cytomegalovirus(CMV) is the most common opportunistic viral agent encountered in AIDS and its relation to peripheral neuropathy and rapidly developing lumbosacral polyradiculopathy has been well documentated. Case : A 30-year-old man with acquired immune deficiency syndrome presented with rapidly progressive paraplegia and voiding difficulty. Electrophysiologic studies revealed a lumbosacral polyradiculopathy with loss of bulbocavernous reflex and CSF examination showed polymorphonuclear pleocytosis with elevated protein level. Also, spinal T1-weighted MRI with gadolinium-DTPA showed enhancement of the pial lining of the conus medullaris, cauda equina, and lumbar nerve roots. Anti CMV titers were elevated in CSF and culture for CMV in both blood and urine was positive. The patient was treated with ganciclovir. Conclusion : We report a case of polyradiculopathy related to CMV in a patient with acquired immune deficiency syndrome(AIDS). It seems to be important to differentiate this unique syndrome from other causes of rapidly developing paraplegia syndromes among AIDS patients. ------------------------------------------------------------------------ Key word : cytomegalovirus, polyradiculopathy, AIDS, ganciclovir