Cognitive Function in Non-Insulin Dependent Diabetic Patients : P300 Event-related Potentials and Neuropsychological Tests

J Korean Neurol Assoc > Volume 15(4); 1997 > Article

Journal of the Korean Neurological Association 1997;15(4): 803-815.

인슐린 비의존성 당뇨병 환자에서의 인지기능에 관한 연구 : 인식 유발전위와 신경심리검사를 중심으로

유봉구, 윤석중, 김광수, 유경무, 최영식, 박요한

고신대학교 의학부 신경과학교실, 내과학교실

Cognitive Function in Non-Insulin Dependent Diabetic Patients : P300 Event-related Potentials and Neuropsychological Tests

Bong Goo Yoo, M.D., Seok Jung Yoon, M.D., Kwang Soo Kim, M.D., Kyung Mu Yoo, M.D., Young Sik Choi, M.D., Yo Han Park, M.D.

Department of Neurology and Internal Medicine, Kosin Medical College

Abstract

Background and Objective : Several recent studies have demonstrated that cognitive function is impaired in non-insulin dependent diabetes mellitus (NIDDM) patients compared with age-matched non-diabetic controls. However, the underlying pathophysiological mechanism of this diabetic central nervous involvement remains obscure. The present study was designed to explore further whether cognitive deficits are present in NIIDDM patients who do not show apparent symptoms and signs of central nervous system damage and to evaluate the influence of clinical parameters and diabetic complications on cognitive function. Methods : Thirty patients over 50 years of age with NIDDM and 30 age-, sex- and education-matched normal controls were recruited for the study. P300 event-related potential test and neuropsychological tests (Mini-Mental State Examination, MMSE; Benton Visual Retention test; Digit Span Forward and Backward) were perfomed. P300 latencies were recorded according to the conventional technique using Counterpointer MK2. Results : Compared with controls, NIDDM patients showed significant impairment in MMSE (P<0.05), Benton Visual Retention (P<0.05), and Digit Span Backward (P