Tc-99m HM-PAO SPECT in migraine between attacks

J Korean Neurol Assoc > Volume 15(3); 1997 > Article

Journal of the Korean Neurological Association 1997;15(3): 624-633.

편두통 환자의 두통이 없는 시기에서의 Tc-99m HM-PAO SPECT 검사

성상민, 김상화, 문인수, 김대성, 정대수, 박규현, 김용기

부산대학교 의대 신경과. 핵의학과

Tc-99m HM-PAO SPECT in migraine between attacks

Sang Min Sung, M.D., Sang Hwa Kim, M.D., In Soo Moon M.D., Dae Seong Kim M.D., Dae Soo Jung M.D., Kyu Hyun Park M.D., Yong Ki Kim M.D.

Department of Neurology and Nuclear Medicine* College of Medicine, Pusan National University

Abstract

Technetium 99m hexamethylene-propyleneamine oxime(Tc 99m HM-PAO) SPECT brain imaging was performed in patients with migraine without aura(n=32) and migraine with aura(n-29) during the headache-free period. A regional alteration of tracer uptake into brain was observed in 21 cases of migraine without aura (65.6%, 18 cases : reduction, 3 cases : increment) and in 20 cases of migraine with aura(69%, all cases reduction, including 10 cases : hemiplegic or hemisensory aura, 10 cases only visual aura). In most cases(73.3%) of migraine with aura, the areas of decreased tracer uptake was exclusively concordant with the areas of unilateral aura. The concordance between the area of associated focal neurological symptom(aura) and the area of regional hypoperfmion was observed in 9 cases(69.2%) of hemiplegic or hemisensory aura(13 cases). The concordance between the site of headache and the areas of regional hypoperfusion or hyperperfusion was observed in 30 cases(49.2%) of migraine with or without aura. Therefore an impaired regional cerebral vascular autoregulation may exist even during headache free intervals in patients suffering migraine with or without aura. It may be concluded that migraine attacks occur in association with exacerbation of preexisting change of cerebral autoregulation.