The expression of the immediate early genes, c-fos, krox-24 and the late response       gene, BKNF induced by antiepileptic drugs

J Korean Neurol Assoc > Volume 15(3); 1997 > Article

Journal of the Korean Neurological Association 1997;15(3): 542-554.

항경련제에 의한 C-FOS, KROX-24 및 BDNF 의 발현

서순천, 박영춘, 김수경

계명대학교 의대 신경과. 약리학과

The expression of the immediate early genes, c-fos, krox-24 and the late response gene, BKNF induced by antiepileptic drugs

Soon-Chun Suh, M.D., Young-Choon Park, M.D., Soo-Kyung Kim, M.D

Department of Neurology and Pharmacology, College of Medicine, Keimyng University

Abstract

The expression of the c-fw and krox 24 (immediate early genes: IEGS) and the BDNF (late response gene) were investigated by convulsants such as kainate (KA, 200 pM), N methyl-D-aspartate (NMDA, 10 mM), glutamate (GLU, 2 mM), and picrotoxin (PTX, 20 uM in the rat C6 glioma cells. In addition, the changes of their expression patterns were investigated by the antimn@isants such as a NMDA antagonist MK-801, phenytoin, phenobarbiw, diazepam, and newer antiepileptic drugs like felbamate and gabapentin. NMDA induced c-fos and krox 2,4 expromiom were decreased spatially by the anticonvulsants. KA, NMDA, GLU, and PTX induced BDNF expression were increased by the anticonvulsants. These results imply the molecular basis of the anticonvulsant action mechanism lies in differential and coordinated transcriptional regulation of IEGS.