Coagulation-Fibrinolysis system in acute progressive and non-progressive stroke 
    -Preliminary study-

J Korean Neurol Assoc > Volume 15(3); 1997 > Article

Journal of the Korean Neurological Association 1997;15(3): 475-480.

급성 진행성 뇌졸중과 비진행성 뇌졸중에서의 응고계 및 섬유소 용해계 -예비적 연구-

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Coagulation-Fibrinolysis system in acute progressive and non-progressive stroke -Preliminary study-

Key chung Park, M.D., dae-il Chang, M.D., Kyung cheon Chung, M.D.

Department of Neurology, Kyung-Hee University, College of Medicine

Abstract

Baekground & Purpose : Fibrinoeptide-A (FpA) and D-dimer have been well known as hematologic parameters for activation of the coagulation and the endogeneous fibrinolysis system during acute phase of ischemic stroke. We measured the levels of FpA and D-dimer in acute progressive and non-progressive ischemic strokes to assess whether these markers are valuable as a predictor of stroke progression during acute phase. Methods : FpA (RIA method) and D dimer (ELISA method) were determined in 54 patients, 9 with acute progressive and 45 with non-progressive within acute stage(<48 hours of onset) of cerebral infarction. Results : Levels of FpA in patients with acute progressive stroke were significantly higher than those in patients with non-progressive stroke, indicating activation of the coagulation system (P = 0.013). And, levels of D-dimer in patients with acute progressive stroke were also higher than those in patients with non-progressive stroke but statistically insignificant(P-0.071). Conclusions : These findings suggest that the coagulation system is more enhanced in progressive stroke than non-progressive one during acute stage of ischemic stroke. Higher levels of FpA are thought to be useful markers to predict stroke in progression. Key Words : Stroke-in progression, Fibrinopeptide-A, Coagulation system