3 Cases of Mononeuropathy Multiplex Associated with Systematic Vasculitis

J Korean Neurol Assoc > Volume 14(4); 1996 > Article

Journal of the Korean Neurological Association 1996;14(4): 1007-1017.

전신성 혈관염에 의한 다발성 단신경병증 3례

김병조, 박건우 송관규 이영호 고성범 한진규 이대희

고려대학교 의과대학신경과학교실, 내과학교실

3 Cases of Mononeuropathy Multiplex Associated with Systematic Vasculitis

Byung Jo Kim, M. D., Kun Woo Park, M. D., Gwan Gyu Song, M. D., Young Ho Lee, M. D., Seong Beom Koh, M. D., Jin Hyo Han, M. D., Dae Hie Lee, M. D.

Department of Neurology, Department of Internal Medicine, Korea University, College of Medicine

Abstract

Peripheral nervous system involvement is common in systemic vasculitis, occurring most frequently in the polyarteritis nodosa (PAN) group of disorders and in rheumatoid vasculitis. Within the polyarteritis nodosa group of systemic necrotizing vasculitides, three subgroups have been described: classic polyarteritis nodosa, Churg-Strauss syndrome, and an overlap syndrome. Three patients with evidence of systemic vasculitis and peripheral neuropathy were clinically and electrophysiologically investigated. All cases presented clinically with mononeuropathy multiples considered typical pattern of ischemic involvement of the peripheral nerve. The causes included polyarteritis nodosa, its Churg-strauss variant, and the overlap syndrome. Pain and weakness were frequent symptoms. Nerve conduction studies were abnormal In all cases. Necrotizing vasculitis was present as pathologic findings in two cases. All patients were treated with prednisolone alone or in combination with other immunosuppressive agents or with plasmapheresis.