Abnormalties of Ocular Motor Movement in Patients with Parkinson's Disease

J Korean Neurol Assoc > Volume 14(3); 1996 > Article

Journal of the Korean Neurological Association 1996;14(3): 754-760.

파킨슨씨병에서의 안구운동 이상

최기종, 김재우, 김상호, 김성률, 김갑진, 박지욱, 박경원

동아대학교 의과대학 신경과학교실

Abnormalties of Ocular Motor Movement in Patients with Parkinson's Disease

Ki Jong Choi, M.D., Jae Woo Kim, M.D., and Sang Jo Kim, M.D., Seong Ryul Kim, M.D.,Kab Jin Kim, M.D., Ji Wook Park, M.D., Kyeong Won Park, M.D.

Department of neurology, College of Medicine, Dong-A University

Abstract

OBJECTIVE : We investigated the relationship between the severity of the disease and the abnormality of some ocular movements in parkinson's disease. BACKGROUND : Disorders of eye movements have been described in diseases of the basal ganglia for over a century and ocular motor deficits of the saccadic and pursuit system have been reported in parkinsonian patients. METHOD : We studied the electro-oculography of the eye tracking and saccadic movement in 26 patients (11 males, 15 females) with Parkinson's disease. The severity of the disease was divided into two groups by Hoehn & Yahr(H-Y) staging, H-Y stage 1, 2(group A) and H-Y stage 3, 4 (Group B). Some patients antiparkinsonian drugs of L-dopa, dopamine agonist and anticholinergics. RESULT : The velocity of smooth pursuit and the velocity and latency of saccade were calculated and compared between two groups. Eye tracking test revealed decreased pursuit velocity leading to catch-up saccades, but normal phase relationship between eye and target movement, while saccadic eye movement had increased latency. These results showed more profound severity in more advanced stages of the disease. CONCLUSION : We suggest that ocular movement be often chosen as a simple but relevant example of general motor function, as well as criteria for staging of Parkinson's disease and basal ganglia play significant role in ocular movement.