Clinical Correlations between Duration of Epilepsy and Anticonvulsant Treatment Response in Temporal Lobe Epilepsy

J Korean Neurol Assoc > Volume 14(2); 1996 > Article

Journal of the Korean Neurological Association 1996;14(2): 433-439.

간질 이환기간이 측두엽 간질의 항경련제 치료 반응에 미치는 영향

박진운, 김장성, 박재현

인제대학교 의과대학 상계백병원 신경과학교실

Clinical Correlations between Duration of Epilepsy and Anticonvulsant Treatment Response in Temporal Lobe Epilepsy

Jin Woon Park, M.D., Jang Sung Kim, M.D., Jae Hyeon Park, M.D.

Department of Neurology, College of Medicine, Inje University, Sanggye Paik Hospital

Abstract

We have studied the clinical correlations between duration of epilepsy and anticonvulsant treatment response in temporal lobe epilepsy. We evaluated correlations between the duration of epilepsy before control and frequencies after six and twelve months of antiepileptic drug treatment, respectively. And we analyzed differences of epilepsy duration between no recurrence group, reduced seizure frequencies below 25% of before control frequencies and reduced seizure frequencies above 25% of before control frequecies groups respectively. We concluded that there are no positive correlations between the duration of epilepsy and seizure frequencies after antiepileptic drug treatment (Spearman correlation coefficients 0.2801 p=0.354 at six months antiepileptic drug treatment, 0.2797 p=0.355 at twelve months). We also concluded that there are no differencies of epilepsy duration between no recurrence group, group with reduced seizure frequencies below 25% of before control frequencies and group with reduced seizure frequencies above 25% of before control frequecies after six months of antlepileptic drug treatment(p=0.6511)and after twelve months of antiepileptic drug treatment (p=0.9469).