| 고혈압과 당뇨병이 허혈성 뇌혈관질환의 위험인자로서의 Lipoprotein(a)에 미치는 영향 |
| 박정욱, 박성경, 이정욱, 김영인, 김용재, 이광수, 김범생 |
| 카톨릭대학교 의과대학 신경과학교실 |
| The Effect of Diabetes and Hypertension to the Role of Lp(a) as a Risk Factor of the Ischemic Cerebrovascular Disease |
| Jeong-Wook Park, M.D., Seong-Keong Park, M.D., Jeong-Wook Lee, M.D., Yeong-In Kim, M.D., Young-Jae Kim, M.D., Kwang-Soo Lee, M.D., Beum-Saeng Kim, M.D |
| Department of Neurology, Catholic University Medical College |
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| Abstract |
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Background and objectives : It had been well known that Lipoprotein(a) had proatherogenic and thrombogenic action because of structural similarity with plasminogen. However the role of Lipoprotein (a) (Lp(a)) in the development of ischemic cerebrovascular disease had not sufficiently clarified. The aim of this study was to evaluate the effect of diabetes mellitus (DM) and hypertension (HBP) to the role of Lp(a) as a risk factor of ischemic cerebrovascular disease. Method : For comparing Lp(a) and the lipid profile of ischemic stroke group (5, N=232) with those of control group (C, N=158) , we divided each group into four subgroups according to the existance of DM and HBP: stroke patients and control subjects with DM only(DMS, N=27; DMC, N=44) , those with HBP only(HBPS, N=94; HBPC, N=44) , those with both of DM and HBP (DMHBPS, N=46; DMHBPC, N=29) , and those with none of DM and HBP(NS, N=65; NC, N=41) . We evaluated Lp(a) and the lipid profile measured less than 72 hour after onset of stroke and 3 month later in 33 ischemic stroke patients. Also we divided the stroke group into two subgroups according to the type (large artery thrombotic vs small artery perforating) and the age of onset (below 50 year-old vs above 50 year-old), and compared Lp(a) and the lipld profile in each subgroups. Result : 1. In control group, the Lp(a) in DMC was significantly higher t that in NC. 2. The Lp(a) compared between HBPC & HBPS and between & NS were statistically significant. 3. The Lp(a) in DMS revealed no significant difference compared with that in DMC. 4, The type of ischemic stroke did not give specific Lp(a) level. 5. The Lp(a) in the young age onset revealed no significant difference compared with that in the old age onset. Conclusion : The Lp(a) is likely to contribute to the ischemic stroke at independent risk factor, However it is seemed that the role of Lp(a) as a risk factor of the ischemic stroke is evaluated after being subdivided according existence of DM. |
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