Clobazam as An Add on Therapy in Patients with Complex

J Korean Neurol Assoc > Volume 13(4); 1995 > Article

Journal of the Korean Neurological Association 1995;13(4): 865-871.

복합부분간질 환자에서 Clobazam의 추가치료

곽용태, 백종삼, 이준홍, 조태영, 박수철, 이병인

연세대학교 신경과

Clobazam as An Add on Therapy in Patients with Complex

Yong Tae Kwak, M.D., Jong Sam Baik, M.D., Joon Hong Lee, M.D., Tae Young Cho , M.D., Soo Chul Park, M.D., Byung In Lee, M.D.

Department of Patholoogy, Severance-Hospital, Yonsei University

Abstract

Clobazam is one of the benzodiazepine compounds consisting of different structure compared to previously marketed other benzodiazepines. In rescent days, the antiepileptic effects of this drug has been recognized and used in epileptic patients. To confirm the efficacy and side effects of clobazam, we review the records of the 60 patients who was medicated clobazam more than 9 months. These patients had complex partial seizure with unsatisfactory control despite of adequate drug dosage and duration. Among these patients, the improved one were 23 (38. 3%), and tolerant one were 25 with 5.6 month mean remission duration. Only the 7 of 60 patients complained the adverse symptoms and this were not serious enough to discontinue medication. In conclusion, clobazam is relatively safe and efficacious medication enough to try for patients with unsatisfactory seizure control.