A Case Report of Progressive Subcortical Gliosis

J Korean Neurol Assoc > Volume 13(3); 1995 > Article

Journal of the Korean Neurological Association 1995;13(3): 696-702.

진행성 피질하 신경교증 -증례보고-

김상윤, 나덕렬, 박성호, 구혜수, 지제근

한림대학교 신경과, 삼성병원 신경과, 보라매병원 신경과...

A Case Report of Progressive Subcortical Gliosis

Sang Yun Kim, M.D., Duk Lyul La, M.D., Seong Ho Park, M.D., Hae Soo Koo, M.D., Je Geun Chi, M.D.

Department of Neurology, College of Medicine, Hallym University, Samsung Medical Center & Boramae City Hospital, Dept of Pathology, College of Medicine, Ewha women's University & Seoul National University

Abstract

A patient presenting with the characteristic clinical features of the dementia of Pick's type is described, in whom neuropathological examination of brain biopsy material revealed atypical features, including extensive subcotical gliosis with mild cortical neuronal loss and without any neuronal cytoskeletal inclusions (Pick bodies, neurofibrillary tangles, and Lewy bodies) and amyloid deposits (senile plaques). And she has the suggestive family history of the same clinical features in her two brothers. So, the clinical and pathological features are discussed with particular reference to typical Alzheimer's disease and Pick's disease, and it is proposed that the case should be classified as familial progressive subcortical gliosis.