| 진행성 핵상 마비 환자에서의 인지기능의 평가: 국소뇌혈류와의 ?상관관계 |
| 이기형, 김경문, 이경한, 전범석, 이상복, 강연욱, 이한보, 박성호 |
| 서울대학교 신경과, 핵의학교실, 충북대학교 심리학과, 보라매 ?시립병원 신경과 |
| Cognitive Function in Progressive Supranuclear Palsy:Correlation ?with Regional Cerebral Perfusion
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| Ki Hyeong Lee, M.D., Gyeong Moon Kim, M.D., Kyung Han Lee, M.D., Beoom S. Jeon, M.D., Sang Bok Lee, M.D., Yekonn Wook Kang, Ph.D., Han Bo Lee, M.D., Seong Ho Park, M.D. |
| Department of Neurology, Nuclear Medicine, College of Medicine, Seoul National University, Dept kof Psychology, Chungbuk Nationial University, Dept of Neurology, Boramae City Hospital |
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| Abstract |
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Although cognitive impairment is commonly included in the clinical manifestation of PSP, the precise nature of these deficits, as well as their anatomical substrates are not clarified. Our, preliminary study and those of others using 99mTc HMPAO brain SPECT or PET showed the derangement of cortical metabolism or blood flow predominantly in frontal area despite the lack of cortical histopathology.
To assess the severity and the specific pattern of cognitive impairment in progressive
supranuclear palsy(PSP) and its correlation with the regional cerebral perfusion, a
neuropsychological battery encompassing measures of intelligence, language functioning,
verbal/visual memory, attention, psychomotor speed and dexterity, visuospatial
construction, mental flexibility, and concept formation and reasoning ability was
administered to patients with PSP and age/sex matched controls.
Patients with PSP had significantly diminished K-WAIS IQ scores when compared with
control subjects, although the patients still had ""average level' IQ scores. And the
patients were particularly impaired when a task required executive and attentional
procedures such as abstract concept formation, reasoning, and conceptual shifting. In
addition, the severity of frontal lobe dysfunction was well correlated with the regional
perfusion index of superior frontal cortex.
These results suggest the frontal lobe dysfunction may be the relatively specific aspect
of cognitive impairment in PSP and well correlates with the regional cerebral perfusion
pattern of PSP.
Key Words : Progressive supranuclear palsy, SPECT, cognitive function |
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