Metabolic Alterations of Acute Cerebral Infarction Evaluated by
Localized, Water-Suppressed In Vivo'H MRS

J Korean Neurol Assoc > Volume 13(3); 1995 > Article

Journal of the Korean Neurological Association 1995;13(3): 417-424.

H-MRS로 측정한 급성 뇌경색의 대사변화

최보영, 한시령.이광수,최규호,김범생,신경섭

카톨릭 대학교 신경과,방사선과

Metabolic Alterations of Acute Cerebral Infarction Evaluated by Localized, Water-Suppressed In Vivo'H MRS

Bo Young Choe, Ph.D., Si Ryung Hahn, M.D., Kwang Soo Lee, M.D., Kyu Ho Choi, M.D., Beum Saeng Kim, M.D., Kyung Sub Shinn, M.D.

Department of Radiology and Neurology, Catholic University Medical College

Abstract

Localized, water-suppressed in vivo 'H MRS was performed to evaluated the proton metabolic alterations in patients with acute cerebral infarction.Ten brain infarction patients(six males and four females; age range 53-77) participated in this study. GE Signa 1.5-T whole-body NMI/MRS system using STEAM pulse sequence was used. Voxels were selected from the cerebral infarcted region and contralateral normal region as control in the same patient. Proton metaboliteratiosrelativetocreatine (Cr) wereobtainedusingaMa-rquartalgorithm. The specific features in the cerebral infarcted regions demonstrated a significant decrease of N-acetyl aspartate (NAA)/creatine (Cr) ratio, compared with control regions. Markedly increased lactate (Lac) level was observed in areas of cerebral infarctioln in all patients. Our preliminary study showed that NAA/Cr ratio in the infarcted regions was substanially different from that in control regions.The signal intensity of Lac may be served as a metabolic criterion that can specify acuteness of infarction, and also evaluate the therapeutic effect. It is necessary to investigate the spectral alterations in various stages of cerebral infarction for further detail analysis. Key Words : MRS, acute cerebral infarction, metabolism