Abnormalities of Coagulation System In Cerebral Infarction

J Korean Neurol Assoc > Volume 13(2); 1995 > Article

Journal of the Korean Neurological Association 1995;13(2): 194-198.

뇌경색의 응고계 이상

장대일, 윤성상, 박기정, 윤상수, 정경천

경희대학교 신경과

Abnormalities of Coagulation System In Cerebral Infarction

Dae Il Chang, M.D., Sung Sang Yoon, M.D., Ki Chung Pack, M.D., Sang Soo Yoon, M.D., Kyung Cheon Chung, M.D.

Department Neurology , Kyung Hee University Hospital

Abstract

Objective. To define the abnormalities of coagulation system in cerebral infarction and the effect of aspirin Background. Toghi et al(1990,1993) suggested that the coagulation system was enhanced at all stages of cerebral infarction and long term use of antiplatelet medication in chronic stroke patients was effective in reducing the elevated coagulant proteins level. Method. We determined fibrinogen, antithrombin III (ATIII), thrombin-antithrombin III complex(TAT) in plasma from 40 stroke patients - 32 acute (<7days), 18 subacute (7-30days) and 32 chronic stage (>30days), and compared 14 patients receiving aspirin from acute stage with 10 patients not receiving aspirin. Result. The concentrations of fibrinogen and TAT were significantly elevated in acute and subacute stages, especially in subacute stage(P<0.01), whereas AT-III was decreased only in acute stage (P