| 근위축성 측삭경화증에서의 혈장내 아미노산 농도에 대한 연구 |
| 이광우, 김병모, 주인수, 엄태현, 홍영준, 김진규 |
| 서울대학교 신경과, 아주대학교 신경과. 임상병리학교실 |
| Studies on Amino Acids Pattern in Amyotrophic Lateral Sclerosis |
| Kwang Woo Lee, M.D., Byung Mo Kim, M.D., In Soo Ju, M.D., Tae Hyun Um, M.D., Young Joon Hong, M.D., Jin Q Kim, M.D. |
| Department of Neurology and Clinical Pathology, College of Medicine, Seoul National University, Department of Neurology, Cellege of Medicine, Ajou University |
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| Abstract |
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Recent researches on ALS pathogenesis are focusing on abnormal immunological factors, excitotoxic substances, neurotrophic factors, and oxidative stress. It is well known that glutamate and aspartate are major putative excitatory neurotransmitters and possess excitotoxic properties that lead to neuronal death. In this study the authors checked the plasma level of amino acids in ALS and control groups and tried to understand any association between excitotoxic amino acids and sporadic ALS.
The concentration of amino acids was measured by the HPLC method in the fasting
plasma of fifteen ALS and nine control subjects. When we evaluated 19 amino acids or
their metabolites, none showed significant difference between ALS and control groups.
The mean concentrations of glutamic acid in ALS and control groups were 42.3+26.7
mmol/L and 57.4+17.0 mmol/L respectively, which showed no significant difference (p>O.
05). It was not possible to compare the level of aspartic acid in ALS and control groups
as the levels were very low in individuals of both groups.
In conclusion, authors could not note any significant correlations between sporadic ALS
and excitotoxic substances, such as glutamate and aspartate. However, further studies
m the excitotoxic levels in cerebrospinal fluid, spinal cord and brain, could be helpful to
understand the overexcitation character of motor neuron by excitatory amino acids. |
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