| 편측 파킨슨 흰쥐모델의 기저핵내 신경펩티드의 변화 |
| 박건우, 이대희,박민규,김병조,고성범,서영석 |
| 고려대학교 신경과, 해부학. |
| Changes of Neuropeptides in the Basal Ganglia of Hemiparkinsonian? Rat Model |
| Kun Woo Park, M.D., Dae Hie Lee, M.D., Min Kyu Park, M.D., Byung Jo Kim, M.D., Sung Bum Ko, M.D., Young Suk Suh, M.D. |
| Department of Neurology, College of Medicine, Korea University, Department of Anatomy, College of Medicine, Korea University |
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| Abstract |
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We used in situ hybridization histochemistry with synthetic oligonucleotide probes to examined the effects of unilateral 6-hydroxydopamine lesions (which eliminated tyrosine hydroxylase mRNA containing cells in mesencephalon) on enkephalin, dynorphin, and substance P mRNA exprssion in the striatum. The expression of tyroxine hydroxylase mRNA on ipsilateral substantia nigra pars compacta, which reflect dopamine activity, totally decreased for 2weeks after lesioning. After lesioning 1week, 2weeks, and 4weeks, a significant increase of the expression of enkephalin mRNA in ipsilateral to the lesioned striatum was observed (p<0.05). Substance P mRNA expressions were depressed significantly in ispsilateral to the lesioned striaturm, whereas enkephalin mRNA expressions were elevated in consecutive sections from striatal aresas in all rat model. The effect of lesions on dynorphin mRNA expressions in ipsilateral to the lesioned striatum less robust, but significant decreased tendency was observed (p<0.05). These data show that the expression of enkephalin, dynorphin and substance P mRNA is differentially regulated by mesostriatal dopaminergic system. |
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