Clinical Experience of Subacute Sclerosing Panencephalitis treated with Alpha-interferon and Ionsiplex

J Korean Neurol Assoc > Volume 12(3); 1994 > Article

Journal of the Korean Neurological Association 1994;12(3): 542-551.

아급성 경화성 범뇌염에서의 Alpha-Interferon과 Inosiplex 치험 ?1례

이상찬, 이성훈,노순기,박규현,김상욱

부산대학교 신경과.

Clinical Experience of Subacute Sclerosing Panencephalitis treated with Alpha-interferon and Ionsiplex

Sang Chan Lee, M.D., Sung Hun Lee, M.D., Sun Ki Rho, M.D., Kyu Hyun Park, M.D., Sang Wook Kim, M.D.

Department of Neurology, Pusan National University

Abstract

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing, chronic persistent fatal central nervous system disease, involving gray and white matter, especially white matter caused by measles virus that affecting children and young adult. 45 to 68% of affected individuals had measles before the age of 2. Current knowledge of the pathogenesis of SSPE involves mutation of the measles virus, resulting in lack of production of the M(Matrix)-protein. No therapeutic maneuvour gas been proven conclusively to be of value. But recently intraventricular alpha-interferon (a-IFN) injection combined with oral inosiplex increase the length of survival and may bring remission or stabilization in SSPE. We report a case of SSPE which was diagnosed by history, clinical manifestation, typical EEG findings, high titer of measles antibodies in cerebrospinal fluid and serum by hemagglutinin inhibition method. We tried intraventricular a-IFN injection via Ommaya reservoir and oral inosiplex.