Motor Learning Induces c-fos Expression in Mouse Cerebellum

J Korean Neurol Assoc > Volume 12(3); 1994 > Article

Journal of the Korean Neurological Association 1994;12(3): 518-526.

생쥐에서 운동학습과 소뇌의 연관성 및 c-fos 유전자 발현에 관한 ?연구

김만호, 전범석

서울대학교 신경과.

Motor Learning Induces c-fos Expression in Mouse Cerebellum

Man-Ho Kim, M.D., Beom-S. Jeon, M.D.

Department of Neurology, College of Medicine, Seoul National University

Abstract

Objective. To examine whether cerebellum participates in motor learning and expresses immediate early gene during motor learning. Background. There are increasing evidences that cerebellum plays a role in motor learning. Motor learning such as skill is one of long term memory that produces structural changes associated with immediate early gene expression. Methods. We destructed mouse cerebellum surgically and compared the motor performance with normal control by using Rota-Rods test. Motor performance was tested on repeated trials to measure learning. We also measured the c-fos mRNA level in the cerebellum at 0, 30, 60 and 120 minutes of motor learning experiment. Results. Motor learning is impaired in the mice with cerebellar lesion. C-fos mRNA level increased in the cerebellum at 30 and 60 minutes during motor learning.