Development and Persistence of Kindling Phenomenon after ?Injections of Pentylenetetrazol in Rats

J Korean Neurol Assoc > Volume 12(3); 1994 > Article

Journal of the Korean Neurological Association 1994;12(3): 375-381.

백서에서 Pentylenetetrazol 주사후 Kindling의 발달 단계 및 지속성

이승환, 이상도,박영춘

계명대학교 신경과.

Development and Persistence of Kindling Phenomenon after ?Injections of Pentylenetetrazol in Rats

Seung Hwan Lee, M.D., Sang Doe Yi, M.D., Young Choon Park, M.D.

Department of Neurology, Keimyung University School of Medicine

Abstract

The development of pentylenetetrazol (PTZ) kindling has been controversial, authors confirmed the development of kindling phenomenon in experimental rats following every second or third day intraperitoneal administration of PTZ(20-25mg/kg) to experimental rats and same amount of saline to control rats. The developmental stage of motor seizure could be categorized into five stages (stage I ; clonic seizure of face and neck, stage II ; clonic seizure of face, neck and forelimbs, stage III ; clonic seizure of forelimbs and body with brief rearing, stage IV ; falling and generalized clonic seizure, stage V ; falling and generalized tonic-clonic seizure with tonic extension of hindlimbs). Linear regression analysis showed that the stages of motor seizure were increased with the number of PTZ injections (Y=0.1361X + 0.1943, p < 0.05). The persistence of kindling state was also observed after a 5-months pause of PTZ injection. This study suggested that PTZ kindling model in rats could be a good animal model of generalized epilepsy.