Effect of Intraischemic Body Temperature on the Acute Brain Edema and Survival Rate During Transient Global Ischemia in Gerbils

J Korean Neurol Assoc > Volume 11(4); 1993 > Article

Journal of the Korean Neurological Association 1993;11(4): 479-486.

Gerbil의 일과성 전뇌허혈모델에서 허혈중 체온이 급성 뇌부종 및 생존률에 미치는 영향

임주혁, 윤병우,노재규

서울대학교 신경과.

Effect of Intraischemic Body Temperature on the Acute Brain Edema and Survival Rate During Transient Global Ischemia in Gerbils

Joo-Hyuk Im, M.D., Byung-Woo Yoon, M.D., Jae-Kyu Roh, M.D.

Department of Neurology , College of Medicine, Seoul National University

Abstract

It has recently been known that the temperature of the brain during a period of transient cerebral ischemia can critically influence neuropathologic outcome in experimental animals. Thus the severity of brain edema may be thought to be changed according to body temperature during acute stage of cerebral ischemia. We investigated the effects of hypothermia and hyperthermia on the acute brain edema during the transient global ischemia in Mongolian gerbils. During 20 miuntes of global ischemia, body temperatures were maintained at 35＊ in the hypothermic group (n=10). 37＊ in the normothermic group (n=10). 39＊ in the hyperthermic group (n=10). Respectively. During the period of reperfusion. Body temperatures were maintained at 37＊ in each group. Two hours after reperfusion. The animals were decapitated and the waler content of the brain was determined by oven dry method. The uater content were high in (1) the hyperthermic group (79.5+0.3%). (2) the normothermic group (79.2+0.2%). (3) the hypothermic group (79.0+0.2%) the control group (78.6+0.3%) in order of amount. Also there were significant differences of the water content among four groups according to the changes of intraischemic body temperature (p<0.05). At the same time we carried out another experiment for comparing the survival rates in each group. The survival rate of the hypothermic group was sillgificantly higher than that of the normothermic or the hyperthermic groups (p<0.005)