A Case of the Generalized Myokymia Associated with Lung Cancer

J Korean Neurol Assoc > Volume 11(3); 1993 > Article

Journal of the Korean Neurological Association 1993;11(3): 421-426.

폐암에 동반된 전신성 섬유성 근간대경련 1예

김지헌, 이상암,선우일남,권기한

연세대학교 신경과. 한림대학교 신경과.

A Case of the Generalized Myokymia Associated with Lung Cancer

Ji-Heon Kim, M.D., Sang-Am Lee, M.D., Il-Nam Sunwoo, M.D., Ki-Han Kwon, M.D.

Department of Neurology, College of Medicine Yonsei University. Department of Neurology, College of Medicine Hallym University

Abstract

There are widely recognized unusual remote neurological manifestations of internal malignancy. However, as far as the author's knowledge, the generalized myokymia associated with myokymic discharge has not been reported as paraneoplastic syndrome earlier. The patient was a 63-year-old female with generalized myokymia and paresthesia for 4months. The nerve conduction study revealed mild sensorimotor polyneuropathy and EMG study showed the generalized myokymic discharges, which were not changed by sleeping or brachial plexus block. The carbamazepine reduced the amount of myokymia and myokymic discharges but not the benzodiazepine. The diagnosis of lung cancer was confirmed by needle aspiration biopsy, and the cell types of lung cancer were mixed undifferentiated and small cell type. By the administration of anti-cancer drugs including cisplatin, the myokymia and myokymic discharges were completely disappeared. The patient died at 8 months after the diagnosis.