Analysis of Prognostic Factors in Polymyositis

J Korean Neurol Assoc > Volume 11(3); 1993 > Article

Journal of the Korean Neurological Association 1993;11(3): 366-372.

다발성 근염의 예후에 미치는 인자

서대원, 임주혁,나정호,홍승봉,이광우,노재규,이상복,명호진

서울대학교 신경과. 서울 신경질환연구소.

Analysis of Prognostic Factors in Polymyositis

D. W. Seo, M.D., J. H. Lim, M.D., J. H. La, M.D., S. B. Hong, M.D., K. W. Lee, M.D., J. K. Roh, M.D., S. B. Lee, M.D., H. J. Myung, M.D.

Department of neurology , College of medicine, Seoul National University

Abstract

Polymyositis is a heterogenous group of disorders of autoimmune or viral origin. Although the diagnostic tests and therapy have recently been improved, the prognostic factors of polymyositis are not yet well known. We investigated clinical features and laborator! Findings of 45 polvmyositis patients who were admitted at Seoul National university Hospital from 1986 till 1990 to evaluate prognostic factors. The results of analysis were as follows : 1. There was no significant differrence in clinical consequences among the groups of pure polymyositis (PM), dermatomyositis (DM) PM/DM associated with connective tissue disease(Mann-Whitney U Test:P>0.8). The incidence of each group was 31.1%. 37.8%. And 26.7% respectively. The proportion of patients showing good response to corticosteroid had no significant differrence among the three groups(Mann-Whitney U Test:P>0.6). Hen we compared the proximal muscle weakness to clinical consequences, the decrement of proximal muscle power as well correlated with consequences(N=4l:Spearman rank correlation anal!sis. R=0.27. P=0.055). 3. The initial level of muscle enzymes uas well correlated with clinical consequences, especially in creatine phosphokinase(CPK =36;Spearrnan rank correlation analysis, r= 0.28 p=0.057). 4. When the degree of muscle weakness was compared to the levels of muscle enzyme.. The level of CPK was significantly correlated with the degree of proximal muscle weakness( N=192; Spearman rank correlation analysis r=0.363, p<0.001). The results suggest that the level of CPK and the degree of proximal muscle weakness may be good indicatioons of prognosis in polymyositis.